larazotide

Larazotide is a synthetic octapeptide derived from the zonula occludens toxin of Vibrio cholerae, developed as a tight junction regulator for restoring intestinal barrier function. It acts primarily as an antagonist of zonulin, a protein that modulates intestinal permeability by opening tight junctions between epithelial cells. By blocking zonulin receptors and promoting tight junction assembly and actin filament rearrangement, larazotide prevents the disassembly of these junctions and reduces paracellular permeability. This mechanism helps prevent gluten fragments from crossing the gut barrier in celiac disease, thereby reducing immune activation and symptoms. Larazotide has been investigated mainly as an adjunct therapy for celiac disease but has also shown potential in other conditions involving increased intestinal permeability[1][2][4][5][6][8].

Brand names

INN-202INN202INN 202

Other names

larazotide acetatelarazotida