Drug intelligence / Profile preview

lascufloxacin

Development stage
Phase 3
Lead developer
Kyorin Pharmaceutical
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

**Lascufloxacin** is a novel 8-methoxy fluoroquinolone antibiotic approved in Japan in 2019 for treating community-acquired pneumonia, otorhinolaryngological infections, and respiratory tract infections. Developed by Kyorin Pharmaceutical, it exhibits potent antibacterial activity against Gram-positive bacteria like *Streptococcus pneumoniae* and *Streptococcus anginosus*, Gram-negative pathogens including *Haemophilus influenzae* and *Klebsiella pneumoniae*, anaerobes, and atypicals such as *Mycoplasma pneumoniae* and *Legionella*. It demonstrates excellent lung tissue penetration and is effective against fluoroquinolone-resistant strains due to its balanced dual inhibition of bacterial enzymes.[1][2][3][5][6]

Brand names
Lasvic
Other names
lascufloxacin hydrochlorideLSFX
02

Targets

TOP2A (DNA topoisomerase II)DNA gyraseTopo IV (Bacterial Topoisomerase IV)

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