lasioglossin-III

**Lasioglossin-III (LL-III)** is a 15-residue cationic antimicrobial peptide derived from the venom of the eusocial bee *Lasioglossum laticeps*, with the sequence H-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Val-Lys-NH₂. It exhibits potent broad-spectrum activity against Gram-positive (*B. subtilis*, *S. aureus*) and Gram-negative (*E. coli*, *P. aeruginosa*) bacteria, fungi (*Candida albicans*), and cancer cells (e.g., leukemia, PC-12, HeLa), while showing low hemolytic activity and minimal toxicity to mammalian cells. LL-III adopts an amphiphilic α-helical conformation upon membrane interaction, preferentially binding bacterial and tumor membranes (rich in anionic lipids like PS or PG) via electrostatic forces from its positively charged Lys residues and hydrophobic interactions, leading to membrane destabilization, lateral lipid reorganization, and content leakage without full lysis; it may also target intracellular components like DNA.[1][2][3][6][8][11]

Other names

LL-III