latanoprost

Latanoprost is a synthetic prostaglandin F2α analog used primarily as an ophthalmic solution to reduce elevated intraocular pressure in patients with open-angle glaucoma and ocular hypertension. It acts as a selective agonist of the prostaglandin F (FP) receptor, increasing the outflow of aqueous humor via the uveoscleral pathway by relaxing ciliary muscle and widening intermuscular spaces. The drug is administered topically to the eye and typically begins lowering intraocular pressure within 3–4 hours after administration, reaching maximum effect at 8–12 hours and lasting for at least 24 hours. Latanoprost is generally well tolerated; common side effects include blurred vision, eye redness, itching, eyelash changes (lengthening or darkening), iris pigmentation changes (especially in mixed-color irises), and mild conjunctival hyperemia. It was first approved for medical use in 1996 and is included on the WHO Model List of Essential Medicines[1][2][5].

Brand names

Xalatan适利达

Other names

拉坦前列素拉坦前列腺素Latanoprost Eye Drops