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latanoprost + diclofenac + dorzolamide

Development stage: Unknown
Lead developer: Aarhus University
Modality: Small Molecules
Administration: Ophthalmic

Overview

This drug is a combination therapy consisting of latanoprost, diclofenac, and dorzolamide, investigated by the University of Aarhus for the treatment of diabetic retinopathy. Latanoprost is a prostaglandin F2-alpha analog that typically reduces intraocular pressure; diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis; and dorzolamide is a carbonic anhydrase inhibitor. The combination was studied in the XAVOT trial to determine its effects on retinal vessel diameter and blood flow disturbances in patients with diabetic retinopathy, exploring whether these pharmacological agents can improve retinal hemodynamics.

Other names: Latanoprost, diclofenac and dorzolamide (eyedrops)

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)PTGFR (Prostaglandin F2 alpha receptor)COM crystal surface (Calcium oxalate monohydrate crystal surface)

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