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latanoprost-eluting contact lens
- Development stage
- Unknown
- Lead developer
- TherOptix
- Modality
- Hydrogel Systems → Drug Delivery Systems, Small Molecules
- Administration
- Ophthalmic
01
Overview
The latanoprost-eluting contact lens is a novel drug delivery system developed by the Massachusetts Eye and Ear Infirmary in collaboration with Harvard Medical School, Boston Children's Hospital, and the Massachusetts Institute of Technology. Designed to treat glaucoma and ocular hypertension, the device consists of latanoprost-poly(lactic-co-glycolic acid) (PLGA) films encapsulated within a methafilcon hydrogel contact lens using ultraviolet light polymerization. This platform provides sustained release of latanoprost, a prostaglandin F2α receptor agonist, for up to one month. By replacing daily eye drops with a continuous-wear lens, the technology aims to significantly improve patient adherence and therapeutic outcomes. Preclinical studies in rabbits and monkeys demonstrated efficacy, and a Phase 1 clinical trial (NCT04500574) has been conducted to evaluate its safety and intraocular pressure-lowering capabilities in humans.
- Other names
- Latanoprost Eluting Contact LensLatanoprost-PLGA contact lensContact Lens Drug Delivery System with latanoprost
02
Targets
PTGFR (Prostaglandin F2 alpha receptor)PTGER1 (Prostaglandin E Receptor 1)PTGER3 (Prostaglandin E2 receptor EP3 subtype)
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