latanoprost free acid

Latanoprost free acid is the biologically active metabolite of the prodrug latanoprost, a prostaglandin F2α (PGF2α) analogue. While topical latanoprost is administered as an isopropyl ester to facilitate corneal penetration, it is rapidly hydrolyzed by endogenous esterases into the free acid form. Latanoprost free acid acts as a potent and selective agonist of the prostanoid FP receptor. Activation of these receptors in the uveoscleral pathway and trabecular meshwork increases the outflow of aqueous humor, effectively lowering intraocular pressure (IOP). Beyond its role as a metabolite of topical drops, a sustained-release (SR) formulation consisting of a biodegradable polymer-drug conjugate is being developed by PolyActiva. This implant is designed for intracameral administration to provide continuous therapeutic levels of the drug over several months, aiming to eliminate the adherence issues associated with daily topical regimens in patients with glaucoma and ocular hypertension.

Other names

17-phenyl-trinor PGF2alpha17-phenyl-trinor prostaglandin F2alphalatanoprost acid