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latex allergen extract
- Development stage
- Unknown
- Lead developer
- Leti
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Percutaneous
01
Overview
Latex allergen extract is a biological allergen extract derived from natural rubber latex (NRL), developed by LETI Pharma GmbH. It contains specific allergenic proteins from *Hevea brasiliensis*, including known allergens such as Hev b 1, Hev b 3, Hev b 5, and Hev b 6.02. The extract is primarily used as a diagnostic skin test reagent to identify IgE-mediated hypersensitivity in individuals suspected of having a latex allergy. Its biological activity is standardized in Histamine Equivalent Prick (HEP) units, using histamine as a reference to ensure consistent potency for clinical diagnosis. The extract works by cross-linking IgE antibodies on the surface of mast cells, triggering a localized allergic reaction that serves as a diagnostic indicator.
- Other names
- natural rubber latex allergen extractHevea brasiliensis allergen extractlatex extract
02
Targets
Timothy grass-specific IgE (Timothy grass-specific immunoglobulin E)BCR (Immunoglobulin G B Cell Receptor)FCER1A (Fc epsilon receptor I alpha)Hevea brasiliensis allergen-specific T-cell receptor (Hev b-specific TCR)
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