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latex sublingual immunotherapy
- Development stage
- Unknown
- Lead developer
- ALK Abelló
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Sublingual
01
Overview
Latex sublingual immunotherapy (SLIT-Latex) is an allergen immunotherapy developed by ALK-Abelló and evaluated by the Department of Allergology at Hospital Santiago Apostol for the treatment of natural rubber latex (NRL) allergy. The active ingredient is a natural rubber latex allergenic extract derived from *Hevea brasiliensis*, formulated as a sublingual solution. The therapy is designed to modulate the IgE-mediated immune response to major latex allergens (such as Hev b 5 and Hev b 6), inducing immunological tolerance by shifting the Th2-skewed allergic response, increasing allergen-specific IgG4 and IgA levels, and reducing basophil activation.
- Brand names
- SLIT-Latex
- Other names
- latex sublingual immunotherapySLIT latexlatex allergen extract
02
Targets
High-affinity immunoglobulin epsilon receptor-bound Immunoglobulin E complex
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