Drug intelligence / Profile preview

LAUR-301

Development stage
Preclinical
Lead developer
Lauren Sciences
Modality
Nanoparticles → Drug Delivery Systems, Recombinant Proteins and Enzymes
Administration
Intravenous
01

Overview

LAUR-301 is a preclinical **nanomedicine** drug candidate from **Lauren Sciences** for **amyotrophic lateral sclerosis** and **motor neuron disease**. It uses the company's **V-Smart** nanoparticle platform to systemically deliver **glial cell-derived neurotrophic factor** after **intravenous** administration, with the stated goal of crossing the blood-brain barrier, targeting deteriorating motor neurons in the brain and spinal cord, and releasing a neuroprotective GDNF payload at sites of degeneration. The program is intended as a disease-modifying neurotrophic therapy designed to protect vulnerable motor neurons and potentially promote neuro-restorative effects in ALS.

Other names
Lauren Sciences GDNF nanomedicineLAUR-301 GDNF nanomedicineLAUR301 GDNF nanomedicineLAUR 301 GDNF nanomedicine
02

Targets

RET (Rearranged during transfection receptor tyrosine kinase)GFRα1 (Glial cell line-derived neurotrophic factor receptor alpha 1)

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