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lauromacrogol 400
- Development stage
- Unknown
- Lead developer
- gepepharm
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Thesit is a topical antipruritic medication containing **lauromacrogol 400** (also known as **polidocanol**). Developed and marketed by **gepepharm**, it is indicated for the symptomatic relief of itching (pruritus) associated with dry skin and various dermatological conditions such as eczema and dermatitis. Lauromacrogol 400 functions as a local anesthetic and non-ionic surfactant; it stabilizes the membranes of sensory nerve endings, reducing their excitability and effectively blocking the transmission of itch sensations to the central nervous system. The product is available as a gel and as a raw substance for customized pharmaceutical compounding.
- Brand names
- Thesit
- Other names
- polidocanollaureth-9laureth9laureth 9polyethylene glycol monododecyl ether
02
Targets
NaV (Voltage-gated sodium channels)
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