Drug intelligence / Profile preview

lauromacrogols + urea

Development stage
Phase 4
Lead developer
Karo Healthcare
Modality
Small Molecules
Administration
Topical
01

Overview

E45 Itch Relief Cream is a topical emollient and anti-pruritic formulation designed to treat dry, itchy skin conditions. It contains two active ingredients: **lauromacrogols** (3.0% w/w) and **urea** (5.0% w/w). Lauromacrogols act as a local anesthetic to desensitize peripheral sensory nerve endings, providing rapid relief from itching (pruritus). Urea is a naturally occurring humectant and keratolytic agent that helps the skin retain moisture and restores the skin's natural barrier function. The product is indicated for the treatment of pruritus, eczema (including atopic dermatitis), dermatitis, and scaling skin conditions. Originally developed and manufactured by Reckitt Benckiser Healthcare, the marketing authorization is currently held by Karo Pharma.

Brand names
E45 Itch Relief CreamE-45 Itch Relief CreamE 45 Itch Relief Cream
Other names
polidocanol + urealauromacrogols + ureaurea + lauromacrogolsurea + polidocanol
02

Targets

Stratum corneum water–protein–lipid matrix

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