Drug intelligence / Profile preview

LB-DTK-MV

Development stage
Phase 2
Lead developer
LucasBio
Modality
Cell Therapies
Administration
Intravenous
01

Overview

LB-DTK-MV is an investigational multi-virus specific T-cell (VST) therapy developed by LucasBio. It consists of T cells that are specifically expanded to recognize and eliminate cells infected with Cytomegalovirus (CMV), BK virus (BKV), and Epstein-Barr virus (EBV). The therapy is designed for patients who have developed antiviral-resistant infections or associated diseases following intensive anticancer therapy or allogeneic hematopoietic stem cell transplantation (allo-HSCT). By restoring the patient's cellular immune response against these opportunistic pathogens, LB-DTK-MV aims to reduce viral loads and improve clinical outcomes in the post-transplant or post-chemotherapy setting.

Other names
Multi-Virus Specific T cellsLucasBio Multi-Virus Specific T cells
02

Targets

BK polyomavirus peptide–Human Leukocyte Antigen complexpp65/HLA-A*02:01 (CMV pp65 peptide-HLA-A*02:01 complex)Epstein–Barr virus peptide–HLA complex

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