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LB-P12
- Development stage
- Preclinical
- Lead developer
- AB-BIOTICS
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
LB-P12 is a probiotic strain developed by AB-BIOTICS for the management of chronic joint pain, osteoarthritis, and overall joint health. The strain functions by modulating the NF-κB and HIF-2α signaling pathways, which are key mediators of inflammation and cartilage homeostasis in the joints. By influencing these pathways, LB-P12 aims to reduce the inflammatory environment and slow the progression of joint degradation. It is part of AB-BIOTICS' therapeutic focus on healthy aging.
02
Targets
EPAS1 (Hypoxia-inducible factor 2-alpha)HDAC (HDAC family)
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