Drug intelligence / Profile preview

LBL-066

Development stage
Preclinical
Lead developer
LEADS BioLabs
Modality
Trispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

LBL-066 is a preclinical-stage trispecific antibody being developed by Nanjing Leads Biolabs for the treatment of solid tumors. As a trispecific antibody, it is engineered to simultaneously bind to three distinct targets, a design typically intended to enhance tumor targeting specificity or to bridge immune cells with tumor cells to facilitate an anti-tumor response. LBL-066 is part of the company's Immuno-Oncology 2.0 (IO 2.0) pipeline, which focuses on next-generation biologics to overcome resistance to current immunotherapies. While its specific molecular targets have not been publicly disclosed, the drug is currently undergoing preclinical evaluation to support future clinical development.

02

Targets

TNFRSF9 (CD137 extracellular domain)CD274 (Programmed cell death protein 1 ligand 1)

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