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LBT-6030

Development stage: Preclinical
Lead developer: Longevity Biotech
Modality: Modified Peptides → Peptides
Administration: Oral

Overview

LBT-6030 is a dual agonist of the glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) receptors, developed by Longevity Biotech using its proprietary Hybridtide™ platform. This technology utilizes peptidomimetic scaffolds incorporating non-natural amino acids and structural modifications to the molecule's interior, resulting in significantly improved metabolic stability and durability compared to conventional peptide drugs. LBT-6030 is designed to treat metabolic conditions such as obesity and type 2 diabetes by mimicking the synergistic effects of natural incretin hormones on weight loss and glucose regulation. The Hybridtide™ platform allows for tunable affinity between the GLP-1 and GIP receptors, potentially optimizing the therapeutic profile for metabolic disorders.

Other names: Hybridtide GLP-1/GIP dual agonist

Targets

GIPR (Gastric inhibitory polypeptide receptor)GLP1R (GLP-1R)

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