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LC115

Development stage: Phase 1
Lead developer: University of Maryland School of Medicine
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Vaginal

Overview

LC115 is an investigational vaginal live biotherapeutic product composed of 15 strains of *Lactobacillus crispatus*. It was designed to restore durable colonization by protective *L. crispatus* following antibiotic treatment for bacterial vaginosis, thereby supporting a vaginal microbiome associated with lower bacterial-vaginosis recurrence. LC115 was evaluated as a vaginal tablet after oral metronidazole in the randomized VIBRANT phase 1 study in the United States and South Africa. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06135974?viewType=Card))

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