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LCAR-BCDR cells
- Development stage
- Discontinued
- Lead developer
- Legend Biotech
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
LCAR-BCDR cells are a universal CAR-T cell therapy developed to target B-cell maturation antigen (BCMA), a protein specifically expressed on mature B lymphocytes and plasma cells. Upon administration, these engineered T cells recognize and kill tumor cells expressing BCMA through immunologic cytotoxicity. The primary indication for LCAR-BCDR is the treatment of relapsed or refractory multiple myeloma. The product is being developed by Nanjing Legend Biotech and is currently in Phase 1 clinical trials[1][2]. As a CAR-T cell therapy, it represents an advanced form of adoptive cell transfer designed to harness the patient’s immune system against hematologic malignancies.
- Other names
- CAR-T-Second Affiliated Hospital of Xi'an Jiaotong University-multiple myelomaCAR-T Re-treatmentBCMA-targeted CAR-T cell re-treatment
02
Targets
BCMA (B-cell maturation antigen)
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