Drug intelligence / Profile preview

lch1

Development stage
Phase 2
Lead developer
Novartis
Administration
Oral
01

Overview

The term "lch1" is highly non-specific in the provided context, referring to several distinct biological entities and a chemotherapy regimen. However, one instance describes "lch1" as a powder of Chinese herb, which is administered to breast cancer patients to evaluate its effects on leucopenia after chemotherapy. This herbal medicine is taken orally from the first chemotherapy cycle until three weeks after the last cycle, for a total duration of approximately 18 to 28 weeks. Its effects on blood cell counts, quality of life, and adverse effects of chemotherapy are being evaluated in a double-blind, placebo-controlled, and randomized clinical trial. The precise mechanism of action for the Chinese herb-LCH1 is not detailed in the provided context, but it is intended to alleviate leucopenia and potentially influence Chinese medical constitutional status. Other mentions of "lch1" include ciliated neurons in Drosophila larvae, a gene (BdLCH1) in Brachypodium distachyon involved in mixed-linkage glucan and starch metabolism, a mutant rice variety (LCH1, Low Cadmium Huanghuazhan 1) with altered cadmium accumulation due to a mutation in the OsNramp5 gene, a plasmid vector (pTip LCH1.2) used for expressing bovine lactoferrin C-lobe, and a recessive gene in rye (Secale cereale L.) affecting meiotic chromosome structure. Additionally, "LCH1-based chemotherapy" is mentioned as a treatment regimen for Langerhans cell histiocytosis, but this refers to a treatment protocol rather than a specific drug named lch1.

Other names
Chinese herb-LCH1

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