LD Vehicle-GNP

LD Vehicle-GNP is a control substance used in clinical trials to evaluate the efficacy of gold nanoparticle-based vaccines. It serves as a vehicle control that contains gold nanoparticles without the active peptide components, allowing researchers to isolate the effect of the peptides from that of the gold nanoparticles themselves[1][2]. ## Composition and Formulation LD Vehicle-GNP refers to the "Low Dose" version of the Vehicle-Gold Nanoparticle control. It consists of gold nanoparticles without the active peptide components that would be present in the actual vaccine candidates[1]. The vehicle was specifically chosen as a control to better isolate the effect of the peptides (such as DENV peptides in dengue vaccine studies or SARS-CoV-2 peptides in COVID-19 studies) from that of the gold nanoparticles themselves[1][2]. ## Clinical Applications This substance has been used in clinical trials for: 1. **Dengue Vaccine Studies**: In the naNO-DENGUE phase 1 trial, Vehicle-GNP was used as a control to assess the safety and immunogenicity of PepGNP-Dengue, a gold nanoparticle-based, multi-valent, synthetic peptide dengue vaccine candidate[1]. 2. **COVID-19 Vaccine Studies**: In trials for PepGNP-Covid19, participants received either the active vaccine candidate or Vehicle-GNP as a control[2]. ## Administration In clinical trials, the Vehicle-GNP was administered in both low dose (LD) and high dose (HD) formulations to match the corresponding doses of the active vaccine candidates[1][2]. The final drug product was lyophilized (freeze-dried) and stored at -20°C, then reconstituted with water for injection before administration[1]. ## Safety Profile According to the limited information available in the search results, vaccinations with Vehicle-GNP were reported as safe in the COVID-19 vaccine trial[2].

Other names

Vehicle-GNPLow Dose Vehicle-GNP