LDN-57444

LDN-57444 is a **small-molecule deubiquitinase inhibitor** used primarily as a research tool rather than an approved therapeutic. It is a reversible, competitive inhibitor of **ubiquitin C-terminal hydrolase L1**, with reported submicromolar potency against UCH-L1 and weaker activity against UCH-L3. In preclinical studies, pharmacologic inhibition of UCH-L1 by LDN-57444 has been used to probe ubiquitin-proteasome pathway biology in cancer, neuroscience, and reproductive biology, including reported inhibition of double-negative prostate cancer colony formation, migration, and metastatic colonization. The compound appears to be a tool compound supplied by research reagent vendors rather than a clinically developed drug, and there is no clear evidence of commercial therapeutic development, regulatory approval, or branded pharmaceutical marketing.

Other names

5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)UCH-L1 inhibitorUCH-L-1 inhibitorUCH-L 1 inhibitorUbiquitin C-terminal hydrolase L1 inhibitor