Drug intelligence / Profile preview

LEAF-1702

Development stage: Unknown
Lead developer: LEAF Pharmaceuticals
Modality: Liposomes → Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
Administration: Intravenous

Overview

LEAF-1702 is a small molecule, liposomal drug developed by L.E.A.F. Pharmaceuticals for the treatment of various cancers. It is a liposomal formulation of gamma-D pentaglutamated pemetrexed-D and acts as an inhibitor of thymidylate synthase (TYMS), disrupting DNA synthesis in rapidly dividing cancer cells. LEAF-1702 belongs to a new generation of onco-immuno antimetabolites designed to disrupt dysregulated serine-glycine 1-carbon metabolism in cancer and the immune system. The drug has reached Phase 1/2 clinical development for indications including head and neck neoplasms, ovarian cancer, and pancreatic cancer[1][2][3][4].

Other names: Liposomal formulation of gamma-D pentaglutamated pemetrexed-D

Targets

TS (Thymidylate synthase)

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