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LEAPS COVID-19 conjugates
- Development stage
- Preclinical
- Lead developer
- CEL-SCI
- Modality
- Peptide-Drug Conjugates → Peptide Conjugates → Peptides, Vaccines & Immunotherapeutics
- Administration
- Injection
01
Overview
LEAPS COVID-19 conjugates are **peptide-based immunotherapeutic conjugates** being developed by **CEL-SCI** for **COVID-19** prevention or treatment using the company's **Ligand Epitope Antigen Presentation System** platform. The conjugates are designed around **conserved SARS-CoV-2 nucleoprotein epitopes** rather than spike, with the aim of inducing **cytolytic T-cell responses** against infected cells while also stimulating antibody and broader cell-mediated immunity and potentially moderating inflammatory cytokine responses. Preclinical studies described improved survival in SARS-CoV-2-challenged mice and rapid antibody generation after a single injection, and the program has been reported in collaboration with the **University of Georgia**.
- Other names
- LEAPS COVID-19 conjugates
02
Targets
N (Nucleocapsid protein)
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