Drug intelligence / Profile preview

lemon balm extract

Development stage
Unknown
Administration
Oral, Topical
01

Overview

Lemon balm extract is derived from the leaves of the Melissa officinalis plant, a member of the mint family. It contains a variety of bioactive compounds including phenolic acids (such as rosmarinic acid), flavonoids, and essential oils. The extract is rich in antioxidants and demonstrates sedative, calming, antiviral, and anti-inflammatory properties. Its proposed mechanisms of action include modulation of GABAergic activity in the central nervous system, inhibition of viral replication (notably herpes simplex virus), and inhibition of pro-inflammatory mediators through cyclooxygenase and NF-κB pathways. Lemon balm extract has been studied for use in alleviating symptoms of anxiety, stress, insomnia, indigestion, and cold sores, though robust clinical evidence is limited and most efficacy claims are based on traditional use or preliminary studies[1][3][5][7].

Brand names
LomaHerpan
Other names
lemon balmMelissa officinalis extractbee balm extractMelissa extract
02

Targets

AcetylcholinesteraseCOXABAT (4-aminobutyrate aminotransferase)GABRR (GABA-A receptor subunit rho)15-LOX (Lysyl Oxidase)GABA-B (Gamma-aminobutyric acid receptor type B)NF-κB

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