Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
lemon balm extract + magnolia bark extract + l-theanine
- Development stage
- Preclinical
- Lead developer
- Nu Skin
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
The combination of lemon balm extract (*Melissa officinalis*), magnolia bark extract (*Magnolia officinalis*), and L-theanine, often abbreviated as TMM in research literature, is an investigational herbal combination being studied for the management of mood disorders. This combination consists of three natural compounds: L-theanine (an amino acid found in tea), *Melissa officinalis* leaf extract, and *Magnolia officinalis* bark extract. It is primarily investigated for its potential anxiolytic (anti-anxiety) and antidepressant activity. The biological targets involve multiple neurotransmitter systems including GABA, serotonin, and dopamine pathways, with demonstrated neuroprotective effects in models of excitotoxicity. While various supplement companies market products containing these three ingredients, such as Nu Skin's MYND360 Feel Calm, the specific research combination TMM is primarily investigated as a natural therapeutic approach for mood disorders including anxiety and depression.
- Brand names
- MYND360 Feel CalmMYND-360 Feel CalmMYND 360 Feel Calm
- Other names
- TMMMelissa officinalis extract + Magnolia officinalis extract + L-theanine
02
Targets
CNR1 (Cannabinoid receptor 1)ABAT (4-aminobutyrate aminotransferase)GABAA (Gamma-aminobutyric acid receptor)
Beyond the preview
Go deeper on lemon balm extract + magnolia bark extract + l-theanine.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on lemon balm extract + magnolia bark extract + l-theanine.