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Drug intelligence / Profile preview
lenalidomide + liposomal doxorubicin
- Development stage
- Preclinical
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous, Oral (lenalidomide)
01
Overview
**Lenalidomide + liposomal doxorubicin** is a combination regimen of lenalidomide, an immunomodulatory and anti-angiogenic small molecule, with liposomal doxorubicin, a nanoparticle-formulated anthracycline chemotherapy. Lenalidomide acts to enhance immune-mediated anti-tumor activity and inhibit tumor angiogenesis, while liposomal doxorubicin delivers doxorubicin in a pegylated-liposome nanoparticle to improve pharmacokinetics and reduce systemic toxicity. The combination is primarily investigated in relapsed/refractory or recurrent hematologic cancers such as multiple myeloma and in recurrent epithelial ovarian cancers, exhibiting synergistic anti-neoplastic effects and an acceptable safety profile as evidenced in early phase clinical studies[1][3].
- Other names
- lenalidomide plus liposomal doxorubicinlenalidomide and liposomal doxorubicinlenalidomide + pegylated liposomal doxorubicin
02
Targets
IKZF3 (Zinc finger protein Aiolos)CK1α (Casein kinase I alpha)CRBN (Cereblon)DNAIKZF1 (Ikaros family zinc finger protein 1)TOP2A (DNA topoisomerase II)
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