Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
lenalidomide oligonucleotide PROTAC
- Development stage
- Preclinical
- Lead developer
- Upstate Medical University
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
- Administration
- Oral, Buccal, Inhalation, Sublingual, Rectal, Vaginal, Intranasal, Transdermal, Parenteral, Intravenous, Intramuscular, Subcutaneous, Intradermal, Intraperitoneal, Intraarticular, Intrathecal, Implant, Intratumoral
01
Overview
lenalidomide oligonucleotide PROTAC is an experimental proteolysis-targeting chimera (PROTAC) designed to target and degrade Abelson Interactor 1 (ABI1), an adaptor protein and transcription regulator that drives metastasis in breast and prostate cancers. The PROTAC consists of an oligonucleotide (DNA) sequence that acts as a bait for the homeobox homology region (HHR) of ABI1, covalently linked via click chemistry to lenalidomide, which recruits the cereblon (CRBN) E3 ubiquitin ligase. By bringing ABI1 into proximity with the CRBN E3 ligase complex, the chimeric molecule induces the ubiquitination and subsequent proteasomal degradation of ABI1, thereby inhibiting cell migration, adhesion, and metastasis.
- Other names
- DNA-based PROTAC targeting ABI1
02
Targets
IKZF3 (Zinc finger protein Aiolos)IKZF1 (Ikaros family zinc finger protein 1)CRBN (Cereblon)
Beyond the preview
Go deeper on lenalidomide oligonucleotide PROTAC.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on lenalidomide oligonucleotide PROTAC.