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Lengzhu granule is a Traditional Chinese Medicine (TCM) formulation developed by the Guangdong Provincial Hospital of Chinese Medicine Zhuhai Hospital. It is currently being investigated in clinical trials for the treatment of coronary heart disease (CHD) and coronary artery disease (CAD) characterized by critical stenosis (50–70%). The therapy is administered as an adjunct to guideline-directed secondary prevention. The clinical evaluation focuses on its efficacy in reducing weekly angina attacks and the need for emergency medication, while its mechanism of action is being explored through the analysis of inflammatory biomarkers and single-cell sequencing to understand its impact on the immune microenvironment and plaque stability.
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