Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
LENTI-COVID-03
- Development stage
- Preclinical
- Lead developer
- Theravectys
- Modality
- Vaccines & Immunotherapeutics, Gene Therapies
- Administration
- Intramuscular, Intranasal
01
Overview
LENTI-COVID-03 is a preclinical-stage, lentiviral vector-based vaccine candidate being developed by Theravectys, in collaboration with the Institut Pasteur, for the prevention of COVID-19 (SARS-CoV-2). The vaccine utilizes a non-integrative lentiviral vector platform pseudotyped with the vesicular stomatitis virus G glycoprotein (VSV-G) and incorporating DNA flap technology to efficiently transduce non-dividing dendritic cells in vivo. This targeted transduction stimulates robust, long-lasting systemic and mucosal humoral (antibody) and cellular (T-cell) immune responses. Preclinical studies have demonstrated that intranasal administration of LENTI-COVID-03 as a booster dose induces strong mucosal immunity, including anti-Spike IgA and resident memory B and T cells in the lungs, providing complete protection against SARS-CoV-2 variants such as Delta and Omicron.
- Other names
- Lenti-COVIDLenti-COVID vaccine candidate
02
Targets
ACE2 (Angiotensin-converting enzyme 2)SARS-CoV-2 spike
Beyond the preview
Go deeper on LENTI-COVID-03.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on LENTI-COVID-03.