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LentiFlash
- Development stage
- Unknown
- Lead developer
- Flash Therapeutics
- Modality
- CRISPR-Cas9 → CRISPR Systems → Programmable Nucleases → Gene Editing → Gene Therapies, Vaccines & Immunotherapeutics, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Local Injection, In Vivo Tissue Injection
01
Overview
LentiFlash is a proprietary **non-integrative lentiviral vector** RNA delivery platform developed by Flash Therapeutics for transient intracellular delivery of therapeutic RNA cargos. The technology uses **bacteriophage-lentiviral chimeras** to introduce RNA into target cells without genomic integration, enabling short-term protein expression and making it suitable for applications such as **gene editing**, **mRNA delivery**, **vaccination**, **immunotherapy**, and **regenerative medicine**. Rather than being a single fixed active substance, LentiFlash is a configurable delivery modality whose specific biological effect depends on the RNA payload; disclosed internal uses include programs in blood and liver diseases and an **APLN-VEGF-C mRNA** combination approach for **secondary lymphedema**.
- Other names
- FlashRNA
02
Targets
LDLR (Low-density lipoprotein receptor)
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