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lenvatinib
- Development stage
- Approved
- Lead developer
- Eisai
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Lenvatinib is an oral small molecule receptor tyrosine kinase inhibitor developed for the treatment of various cancers. It inhibits multiple targets involved in tumor angiogenesis and cancer progression, including vascular endothelial growth factor receptors (VEGFR1, VEGFR2, VEGFR3), fibroblast growth factor receptors (FGFR1–4), platelet-derived growth factor receptor alpha (PDGFRα), KIT, and RET proto-oncogene. By blocking these kinases, lenvatinib disrupts signaling pathways that promote tumor cell proliferation and new blood vessel formation. Lenvatinib is approved for use as monotherapy or in combination with other agents to treat differentiated thyroid cancer refractory to radioactive iodine therapy, advanced renal cell carcinoma (with everolimus or pembrolizumab), unresectable hepatocellular carcinoma, endometrial carcinoma (with pembrolizumab), and unresectable thymic carcinoma in some regions.
- Brand names
- LenvimaKisplyx
- Other names
- lenvatinib mesylate
02
Targets
FGFR4 (Fibroblast growth factor receptor 4)PDGFRA (Platelet-derived growth factor receptor alpha)KIT (c-KIT proto-oncogene receptor tyrosine kinase)FGFR3 (Fibroblast growth factor receptor 3)VEGFR3 (Vascular endothelial growth factor receptor 3)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)FGFR1 (Fibroblast growth factor receptor 1)RET (Rearranged during transfection receptor tyrosine kinase)FGFR2 (Keratinocyte growth factor receptor)
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