Lersivirine + methadone

Lersivirine + methadone is a combination of two drugs. Lersivirine (UK-453,061) is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) developed for the treatment of HIV-1 infection. Methadone is a synthetic opioid used primarily for the management of severe pain and as maintenance therapy or detoxification in opioid use disorder. Lersivirine acts by inhibiting HIV-1 reverse transcriptase and thereby blocking viral replication. Methadone works as a full agonist at the µ-opioid receptor and also antagonizes N-methyl-D-aspartate (NMDA) receptors to relieve pain and prevent withdrawal symptoms in opioid-dependent individuals. Clinical studies have shown that co-administration of lersivirine with methadone does not result in clinically relevant changes in methadone concentrations or withdrawal symptoms; no dose adjustment is required when these drugs are used together.

Other names

DisketsMethadose Sugar-Free