let-7b-5p inhibitor

The let-7b-5p inhibitor is a research-use oligonucleotide reagent designed to silence the endogenous mature microRNA let-7b-5p. It is a chemically modified, antisense single-stranded oligonucleotide (typically featuring full-length 2'-methoxy modifications) that hybridizes with let-7b-5p, preventing the miRNA from binding to its target mRNAs. By inhibiting let-7b-5p function, the reagent allows for the upregulation of target genes such as HK2, DDX19A, NKD1, and those in the FTO/MYC signaling pathways. Preclinical research has utilized this inhibitor to study its effects on cell growth, viability, and self-renewal in various malignancies, including glioblastoma, ovarian cancer, breast cancer, colon cancer, and leukemia. It is primarily available through reagent suppliers for laboratory use and is not intended for human therapeutic applications.

Other names

hsa-let-7b-5p inhibitorhsa-let7b-5p inhibitorhsa-let 7b-5p inhibitorlet-7b-5p antagomirlet7b-5p antagomirlet 7b-5p antagomirlet-7b-5p antimirlet7b-5p antimirlet 7b-5p antimir