letrozole

Letrozole is a nonsteroidal aromatase inhibitor used primarily to treat hormone receptor-positive breast cancer in postmenopausal women. It works by inhibiting the enzyme aromatase, which converts androgens into estrogens in peripheral tissues. By reducing estrogen levels, letrozole slows or stops the growth of certain types of breast cancer cells that require estrogen for proliferation. Letrozole is typically administered orally as a tablet once daily and may be used as first-line therapy, following surgery or radiation, after prior treatment with tamoxifen, or for advanced/metastatic disease. Beyond its primary indication in breast cancer, letrozole has also been studied off-label for conditions such as infertility (ovulation induction), gynecomastia, endometriosis, and other hormonally sensitive tumors[1][4][5][9].

Brand names

Femara

Other names

letrozole