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Leucocyte and Platelet-Rich Fibrin
- Development stage
- Unknown
- Lead developer
- UZ Leuven
- Modality
- Cell Therapies
- Administration
- Local
01
Overview
Leucocyte and Platelet-Rich Fibrin (L-PRF) is an autologous, second-generation platelet concentrate used as a bioactive scaffold in regenerative medicine and dentistry. Developed for endodontic applications by Universitaire Ziekenhuizen KU Leuven, it is prepared by centrifuging a patient's own blood without anticoagulants to form a fibrin clot rich in platelets, leucocytes, and a variety of growth factors, including TGF-β1, VEGF, and PDGF. In the context of regenerative endodontic procedures (REP), L-PRF is placed into the root canal of immature permanent teeth affected by pulp necrosis and apical periodontitis. It serves as a three-dimensional matrix that promotes periapical bone healing, stimulates stem cell migration, and supports continued root development (apexogenesis) by providing a sustained release of bioactive molecules.
- Other names
- Leucocyte- and Platelet-Rich FibrinChoukroun's L-PRFAutologous L-PRF
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