levobupivacaine

Levobupivacaine is a long-acting amino-amide local anesthetic and the single S-enantiomer of bupivacaine. It produces local and regional anesthesia or analgesia by reversibly inhibiting voltage-gated ion channels, principally voltage-gated sodium channels, thereby preventing initiation and propagation of peripheral nerve action potentials. It is administered as a preservative-free solution for infiltration, peripheral nerve block, epidural anesthesia and analgesia, intrathecal anesthesia, and selected ophthalmic blocks. Levobupivacaine has been marketed as **Chirocaine** and has also been evaluated extensively as a regional anesthetic component in perioperative studies, including breast-cancer surgery; these studies concern analgesia rather than direct treatment of cancer. ([accessdata.fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/nda/99/20997_CHIROCAINE_prntlbl.pdf))

Brand names

Chirocaine

Other names

S-bupivacaineS(-)-bupivacaine(S)-bupivacaine