levobupivacaine + bupivacaine

This refers to a specific analgesic regimen evaluated in a clinical trial at the Golden Jubilee National Hospital for postoperative pain management in patients undergoing total knee arthroplasty due to osteoarthritis. The protocol utilizes Patient Controlled Epidural Analgesia (PCEA) to deliver a combination of local anesthetics. Specifically, the regimen involves an initial administration of 0.25% levobupivacaine followed by patient-controlled boluses of 0.125% bupivacaine via an epidural catheter. Both levobupivacaine and bupivacaine are aminoamide local anesthetics that provide regional anesthesia by blocking voltage-gated sodium channels on the internal surface of nerve cell membranes. This blockade prevents the transient increase in permeability to sodium ions, thereby inhibiting nerve impulse propagation and providing effective pain relief.

Brand names

ChirocaineMarcaineExparel

Other names

Patient Controlled Epidural AnalgesiaPatient Controlled Epidural-Golden Jubilee National Hospital-osteoarthritis