levobupivacaine + magnesium sulfate

Levobupivacaine + magnesium sulfate is a combination of two agents used primarily as an adjuvant regimen for regional anesthesia and postoperative pain management. Levobupivacaine is the S(-)-enantiomer of bupivacaine, a long-acting local anesthetic that blocks voltage-gated sodium channels in neuronal membranes, thereby inhibiting nerve impulse transmission and providing local or regional anesthesia. Magnesium sulfate acts as an N-methyl-D-aspartate (NMDA) receptor antagonist, reducing central sensitization to pain by blocking calcium influx into neurons at the spinal cord level. When combined, magnesium sulfate enhances the analgesic effect of levobupivacaine by prolonging sensory and motor block duration, improving postoperative analgesia quality, reducing opioid consumption and rescue analgesic requirements, and increasing patient satisfaction without significant additional side effects. This combination has been studied in various settings including epidural anesthesia for abdominal/pelvic surgeries, periarticular injection after knee arthroplasty, femoral nerve block for ACL reconstruction surgery, and intraperitoneal instillation after laparoscopic procedures[1][6][8][9][10].

Other names

levobupivacaine hydrochloridemagnesium sulphateepidural levobupivacaine with magnesium sulphate adjunct