levocarnitine + clomiphene citrate

Levocarnitine + clomiphene citrate is an investigational combination therapy being evaluated for the induction of ovulation in women with polycystic ovary syndrome (PCOS). Clomiphene citrate is a selective estrogen receptor modulator (SERM) that serves as a standard first-line treatment for infertility in PCOS by antagonizing estrogen receptors in the hypothalamus, which increases the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Levocarnitine (L-carnitine) is a naturally occurring amino acid derivative and nutritional supplement that plays a vital role in energy metabolism by transporting long-chain fatty acids into the mitochondria for beta-oxidation. In this combination, levocarnitine is used as an adjunct to improve metabolic parameters, reduce oxidative stress, and enhance the efficacy of clomiphene citrate in achieving ovulation and pregnancy. This specific intervention has been primarily studied in clinical trials conducted by Ain Shams University.

Other names

L-carnitine + clomiphene citratelevocarnitine and clomiphene citratelevocarnitine-Ain Shams University-polycystic ovary syndrome