levomefolate + methylcobalamin + pyridoxal 5-phosphate

Pyrifol-M is an oral combination vitamin product developed by Solis Pharma, containing the biologically active forms of vitamins B9 (levomefolate), B12 (methylcobalamin), and B6 (pyridoxal 5-phosphate). Unlike synthetic folic acid or pyridoxine, these coenzymated forms do not require extensive metabolic conversion, making them highly effective for individuals with enzymatic deficiencies. The formulation is primarily indicated for the management of nutritional deficiencies and hyperhomocysteinemia, and it is frequently used to support neurological health in conditions such as diabetic peripheral neuropathy. Levomefolate facilitates DNA synthesis and the remethylation of homocysteine to methionine, while methylcobalamin serves as an essential cofactor for methionine synthase. Pyridoxal 5-phosphate acts as a coenzyme for numerous enzymatic reactions, including the transsulfuration pathway that further regulates homocysteine levels.

Brand names

Pyrifol-M

Other names

Methyl Folate 1mg, Methylcobalamin 1500mcg & Pyridoxal 5 Phosphate 5mg Tablets