levonordefrin

Levonordefrin is a synthetic sympathomimetic amine and the levoisomer of nordefrin. It is primarily used as a vasoconstrictor in local anesthetic solutions for dental procedures and as a topical nasal decongestant. Levonordefrin acts mainly by stimulating adrenergic receptors—specifically as a non-selective agonist at α1-, α2-, and β-adrenergic receptors with preferential activity at the α2-adrenergic receptor. Its pharmacologic effects are similar to those of epinephrine but it is more stable and less potent in raising blood pressure or causing vasoconstriction at equal concentrations. Levonordefrin does not cross the blood-brain barrier and its side effects are peripheral. It is rapidly metabolized by catechol-O-methyltransferase with an elimination half-life of 1–3 minutes[1][5][7].

Brand names

Neo-Cobefrine

Other names

corbadrine