Drug intelligence / Profile preview

levonorgestrel + ethinyl estradiol + ferrous fumarate

Development stage
Unknown
Lead developer
FHI 360
Modality
Small Molecules
Administration
Oral
01

Overview

Combined oral contraceptives-FHI 360 refers to a specific contraceptive regimen consisting of levonorgestrel (a progestin), ethinyl estradiol (an estrogen), and ferrous fumarate (an iron supplement). In the context of the LISA (Levonorgestrel Intrauterine System effects on Anemia) trial led by FHI 360, this regimen is used as a comparator to the levonorgestrel intrauterine system (LNG-IUS). The product, often branded as Femiplan, is designed to provide effective contraception while simultaneously addressing iron-deficiency anemia in women. The hormonal components work by inhibiting ovulation and thickening cervical mucus, while the ferrous fumarate provides supplemental iron during the placebo/withdrawal bleed phase of the cycle.

Brand names
Femiplan
Other names
combined oral contraceptives-FHI 360COC/ferrous fumarateLNG/EE/ferrous fumarate
02

Targets

PR (Progesterone receptor)AR (Adrenergic receptors)ER (Estrogen receptor)

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