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Combined oral contraceptives-FHI 360 refers to a specific contraceptive regimen consisting of levonorgestrel (a progestin), ethinyl estradiol (an estrogen), and ferrous fumarate (an iron supplement). In the context of the LISA (Levonorgestrel Intrauterine System effects on Anemia) trial led by FHI 360, this regimen is used as a comparator to the levonorgestrel intrauterine system (LNG-IUS). The product, often branded as Femiplan, is designed to provide effective contraception while simultaneously addressing iron-deficiency anemia in women. The hormonal components work by inhibiting ovulation and thickening cervical mucus, while the ferrous fumarate provides supplemental iron during the placebo/withdrawal bleed phase of the cycle.
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