levopraziquantel

Levopraziquantel is the active levorotatory enantiomer of praziquantel, a small molecule anthelmintic used primarily for the treatment of schistosomiasis and other parasitic worm infections. Unlike racemic praziquantel, which contains equal proportions of levo- and dextro-praziquantel, levopraziquantel by itself is responsible for the antihelminthic activity, while the dextro form contributes mainly to bitterness. Studies demonstrate levopraziquantel is as effective as the racemic mixture at half the dose, with fewer side effects[2][5][7]. It is being developed in orodispersible tablet formulations for pediatric use to improve dosing precision, tolerability, and palatability. The mechanism of action involves increased cell membrane permeability in worms, leading to rapid muscle contraction, vacuolization, and tegument disintegration[2][7]. Primary indication is schistosomiasis, especially in pediatric populations.

Brand names

None known for levopraziquantel specifically

Other names

levopraziquantellevo-praziquantelL-PZQR-(-)-praziquantelarpraziquantel (sometimes used for this enantiomer)