Drug intelligence / Profile preview

levothyroxine

Development stage
Approved
Lead developer
AbbVie
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

Levothyroxine is a synthetic form of the thyroid hormone thyroxine (T4), used primarily to treat hypothyroidism—a condition where the thyroid gland does not produce enough thyroid hormone. It is also indicated for suppressing various types of goiter and as an adjunct in the management of certain types of thyroid cancer alongside surgery and radioactive iodine therapy. Levothyroxine works by replacing or supplementing endogenous thyroxine levels in the body to restore normal metabolic activity regulated by thyroid hormones. The drug reverses symptoms associated with low thyroid hormone such as fatigue, weight gain, cold intolerance, and slowed metabolism[1][2][3][4][5].

Brand names
SynthroidLevoxylUnithroidTirosintEuthyroxEltroxinErmezaLevo-TLevothroidNp ThyroidThyquidity
Other names
thyroxine
02

Targets

THRB (Thyroid hormone receptor beta)αVβ3 (Integrin αVβ3)THRA (Thyroid hormone receptor alpha)

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