Drug intelligence / Profile preview

Levothyroxine + iodide

Development stage
Approved
Lead developer
AbbVie
Modality
Small Molecules
Administration
Oral
01

Overview

Levothyroxine + iodide is a fixed-dose combination drug containing levothyroxine (a synthetic form of the thyroid hormone thyroxine, T4) and an iodide salt, typically potassium iodide. This combination is used to treat hypothyroidism and related thyroid disorders, particularly in regions or clinical situations where iodine deficiency may contribute to thyroid dysfunction. Levothyroxine acts by replacing deficient endogenous thyroxine, thereby restoring normal metabolic activity regulated by thyroid hormones. Iodide serves as a substrate for the synthesis of endogenous thyroid hormones within the gland. The combination ensures both hormone replacement and adequate iodine supply for optimal thyroid function.

Brand names
L-Thyroxin Henning 75 plusL-Thyroxin Jod AristoJodthyrox
Other names
levothyroxine + potassium iodide
02

Targets

THRB (Thyroid hormone receptor beta)NIS (Human sodium iodide symporter)THRA (Thyroid hormone receptor alpha)Neuraminidase

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