Drug intelligence / Profile preview

levothyroxine + liothyronine

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Levothyroxine + liothyronine is a combination drug containing two synthetic thyroid hormones used primarily for the treatment of hypothyroidism and certain other thyroid disorders. Levothyroxine (T4) and liothyronine (T3) are both naturally occurring hormones produced by the thyroid gland. Levothyroxine acts as a prohormone that is converted in peripheral tissues to the more active triiodothyronine (liothyronine). Together, these hormones regulate metabolism, energy production, protein synthesis, body temperature, and organ function. The combination therapy aims to restore normal levels of both T4 and T3 in patients whose bodies do not produce enough endogenous hormone or who have persistent symptoms despite monotherapy with levothyroxine. It may also be used as adjunctive therapy in certain cases of thyroid cancer or goiter management[1][2][3][10].

Brand names
AdthyzaThyrolar
Other names
levothyroxine and liothyronine tabletsthyroid tablets USP
02

Targets

THRB (Thyroid hormone receptor beta)THRA (Thyroid hormone receptor alpha)

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