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LGG-bEVs
- Development stage
- Preclinical
- Lead developer
- University of Cincinnati
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
LGG-bEVs are extracellular vesicles derived from the probiotic bacterium Lactobacillus rhamnosus GG (LGG). These bacterial extracellular vesicles (bEVs) function as therapeutic agents by delivering specific cargo, notably 5s-rRNA-derived short RNA fragments, to macrophages. In the context of myocardial ischemia/reperfusion (I/R) injury, LGG-bEVs stimulate macrophage efferocytosis—the process of clearing dead cardiomyocytes—thereby limiting sterile inflammation and cardiac remodeling. Mechanistically, the RNA cargo interacts with the coding regions of genes such as DDX5, YWHAZ, and FRMD4A, upregulating their expression to enhance phagocytic activity. Research conducted by institutions like the University of Cincinnati has demonstrated that systemic administration of LGG-bEVs in mouse models reduces inflammatory cytokine levels (IL-6, TNF-α, MCP-1) and improves long-term cardiac function post-infarction.
- Other names
- Lactobacillus rhamnosus GG-derived extracellular vesiclesprobiotic extracellular vesicles from LGG
02
Targets
YWHA (14-3-3 protein family)DDX5 (Phosphorylated-p68 RNA helicase)FRMD4A (FERM domain-containing protein 4A)
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