Drug intelligence / Profile preview

LGM mouthwash

Development stage
Unknown
Lead developer
Ameritek
Modality
Small Molecules
Administration
Topical
01

Overview

**LGM mouthwash** is an investigational topical oral formulation developed by Ameritek USA for eradication of oral *Helicobacter pylori*. It contains lysine at 0.4% and glycerol monolaurate at 0.2%. The formulation is intended to eliminate oral *H. pylori*, which may act as a reservoir contributing to persistence or reinfection of gastric *H. pylori* infection. Lysine is described as disrupting the bacterial outer membrane, while glycerol monolaurate has direct anti-*H. pylori* activity. In a completed Phase 1/2 study, use of the mouthwash alongside gastric eradication therapy was associated with an increase in gastric eradication success from 61.33% to 82.26%; reported effectiveness against oral *H. pylori* infection was 72.58%.

Other names
LGM mouthwashLGM mouthwash solutionlysine + glycerol monolaurate mouthwash
02

Targets

H. pylori (Helicobacter pylori)

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