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LH-2417
- Development stage
- Unknown
- Lead developer
- Jiangsu Lianhuan Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
LH-2417 is a novel small molecule 5α-reductase inhibitor being developed by Jiangsu Lianhuan Pharmaceutical for the treatment of benign prostatic hyperplasia (BPH). It functions by inhibiting the enzyme steroid 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT), the primary androgen driving prostate growth and enlargement. By reducing systemic and intraprostatic DHT levels, LH-2417 aims to alleviate lower urinary tract symptoms (LUTS) associated with BPH. As of 2024, the compound is in Phase 1 clinical development, including studies to evaluate its safety, pharmacokinetics, and potential drug-drug interactions with other common BPH and erectile dysfunction therapies, such as the PDE5 inhibitor tadalafil.
- Other names
- apleter
02
Targets
SRD5A1 (Steroid 5-alpha-reductase type 1)SRD5A2 (Steroid 5-alpha-reductase type II)
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